The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis.
Open accessAbstract
Administration of gamma-glutamylcystine or of gamma-glutamylcysteine disulfide to mice leads to significantly increased levels of glutathione in the kidney as compared to controls given glutamate plus cysteine (or cystinylbisglycine). Studies with gamma-glutamylcystine selectively labeled with 35S in either the internal or external S atom indicate preferential utilization of the gamma-glutamylcysteine moiety of this compound for glutathione synthesis. Mice depleted of glutathione by treatment with buthionine sulfoximine do not significantly use the disulfides gamma-glutamylcystine or gamma-glutamylcysteine disulfide but do use gamma-glutamylcysteine for glutathione synthesis. These findings suggest a pathway in which gamma-glutamylcystine, formed by transpeptidation between glutathione and cystine, is transported and reduced by transhydrogenation with glutathione to cysteine and gamma-glutamylcysteine; the latter is used directly for glutathione synthesis. The findings show transport of gamma-glutamyl amino acids, indicate an alternative pathway of glutathione synthesis, and demonstrate a means of increasing kidney glutathione levels.
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Cites
Griffith, O. W., & Meister, A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35980-5 · Cited by 1,683
Self-citation
Cited by
Metabolism and functions of glutathione in brain
Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702
Selective Modification of Glutathione Metabolism
Meister, A. (1983) · Science · doi:10.1126/science.6836290 · Cited by 1,267
Self-citationMeister, A. (1991) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(91)90076-x · Cited by 907
Self-citationDringen, R., Pfeiffer, B., & Hamprecht, B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00562.1999 · Cited by 589
Regulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells
Mann, G. E., Yudilevich, D. L., & Sobrevia, L. (2003) · Physiological Reviews · doi:10.1152/physrev.00022.2002 · Cited by 430
Metadata
- Authors
- Anderson, M. E., & Meister, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-02
- Volume
- 80
- Issue
- 3
- Pages
- 707-711
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2095574453
- Cited by
- 240
- References
- 1
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Anderson, M. E., & Meister, A. (1983). Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.3.707
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
