The DOI matches its Crossref record.
Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation.
Open accessAbstract
The levels of histone mRNA are rapidly reduced after treatment of cultured cells with hydroxyurea or cytosine arabinonucleoside. The histone mRNA for the replicative histone variants is destroyed rapidly, with a half-life of 10-15 min. The levels of mRNA coding for the replacement histone variant H3.3 were unchanged after treatment with DNA synthesis inhibitors. In addition to the rapid destruction of histone mRNA, there was a reduction to 1/5th in the rate of transcription of the histone genes. Lymphoma cells (S49) arrested in G1 by cyclic AMP produce and contain significant levels of histone mRNA. Hydroxyurea reduces the rate of transcription and the levels of histone mRNA in the G1-arrested cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Levels of c-myc oncogene mRNA are invariant throughout the cell cycle
Thompson, C. B., Challoner, P. B., Neiman, P. E., & Groudine, M. (1985) · Nature · doi:10.1038/314363a0 · Cited by 406
John, M. E., John, M. C., Ashley, P., MacDonald, R. J., Simpson, E. R., & Waterman, M. R. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.18.5628 · Cited by 119
Wang, Z. F., Krasikov, T., Frey, M. R., Wang, J., Matera, A. G., & Marzluff, W. F. (1996) · Genome Research · doi:10.1101/gr.6.8.688 · Cited by 70
Metadata
- Authors
- Sittman, D. B., Graves, R. A., & Marzluff, W. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-04
- Volume
- 80
- Issue
- 7
- Pages
- 1849-1853
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2094811739
- Cited by
- 270
- References
- 0
- FWCI
- 9.35
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation. https://app.cochat.ai/papers/10.1073/pnas.80.7.1849
- The paper
- Sittman, D. B., Graves, R. A., & Marzluff, W. F. (1983). Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.7.1849
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
