The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells.
Open accessAbstract
The Epstein-Barr viral (EBV) genome of approximately equal to 170 kilobase pairs (kbp) is maintained as a plasmid in human B lymphoblasts transformed by the virus. We have identified a cis-acting element within 1.8 kbp of the viral genome that allows recombinant plasmids carrying it to be selected at high frequency and maintained as plasmids in cells latently infected by EBV. This functional element(s) requires a segment of DNA at least 800 bp and at most 1800 bp long, which contains a family of 30-bp tandem repeats at one end. Since this region confers efficient stable replication only to plasmids transfected into cells containing EBV genomes, its function probably requires trans-acting products encoded elsewhere in the viral genome.
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Cites
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Cited by
Human induced pluripotent stem cells free of vector and transgene sequences
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Epstein–Barr virus latent genes
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Detection of herpes simplex virus type 1 transcripts during latent infection in mice
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Episomal vectors for gene expression in mammalian cells
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Metadata
- Authors
- Yates, J., Warren, N., Reisman, D., & Sugden, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-06
- Volume
- 81
- Issue
- 12
- Pages
- 3806-3810
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2047197428
- Cited by
- 668
- References
- 28
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Yates, J., Warren, N., Reisman, D., & Sugden, B. (1984). A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.12.3806
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
