The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.
Open accessAbstract
Previous studies had revealed that DNA with partial similarity to the myc oncogene (N-myc) is frequently amplified in human neuroblastoma cell lines and neuroblastoma tumors. We show here for one patient that N-myc amplification is confined to the neuroblastoma tumor and is not present in normal tissue. N-myc mRNA approximately equal to 4.0 kilobases in size is detectable in neuroblastoma cell lines and tumors and in a retinoblastoma cell line. By contrast, appreciable amounts of this RNA were not present in a number of cell lines derived from other human tumors and in fibroblasts from a normal individual and from a neuroblastoma patient. Low levels of N-myc RNA were found in human and murine neuroblastoma cell lines lacking amplification of this gene, up to 80-fold greater levels in all cell lines carrying amplified N-myc. In situ hybridization to sections of neuroblastoma tumors revealed high expression of N-myc predominantly in undifferentiated neuroblasts. We hypothesize that amplification and consequent elevated expression of N-myc may be related to malignant progression.
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Cites
Alitalo, K., Schwab, M., Lin, C. C., Varmus, H. E., & Bishop, J. M. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.6.1707 · Cited by 761
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Cited by
Reflecting on 25 years with MYC
Meyer, N., & Penn, L. Z. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2231 · Cited by 1,575
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture
Schwab, M., Varmus, H. E., & Bishop, J. M. (1985) · Nature · doi:10.1038/316160a0 · Cited by 288
Self-citationCarabet, L. A., Rennie, P. S., & Cherkasov, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010120 · Cited by 172
“Discovery of methyl 4′-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization.”
Background
Metadata
- Authors
- Schwab, M., Ellison, J., Busch, M., Rosenau, W., Varmus, H. E., & Bishop, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-08
- Volume
- 81
- Issue
- 15
- Pages
- 4940-4944
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2024545138
- Cited by
- 400
- References
- 1
- FWCI
- 30.87
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma. https://app.cochat.ai/papers/10.1073/pnas.81.15.4940
- The paper
- Schwab, M., Ellison, J., Busch, M., Rosenau, W., Varmus, H. E., & Bishop, J. M. (1984). Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.15.4940
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
