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A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon.
Open accessAbstract
Three fibronectin mRNAs exist in rat liver, differing by the presence or absence of segments of 285 or 360 bases at a point within the coding region. We previously proposed that the three mRNAs are encoded by a single gene and arise via alternative splicing of a common transcript. In order to test this hypothesis, we have isolated clones spanning approximately half of the fibronectin gene from a Fisher rat genomic library; blot hybridization analyses reveal the presence of only one fibronectin gene in the haploid rat genome. We determined the sequence of a portion (1221 nucleotides) of this gene. This sequence shows clearly that the three fibronectin mRNAs encoded by this gene are generated by a pattern of alternative splicing in which one 5' splice site can be paired with any one of three 3' splice sites, one at the beginning of, and two within, a single complex exon.
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Citations
Cited by
Molecular Biology of Fibronectin
Hynes, R. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.000435 · Cited by 601
Self-citationHumphries, M. J., Akiyama, S. K., Komoriya, A., Olden, K., & Yamada, K. M. (1986) · The Journal of cell biology · doi:10.1083/jcb.103.6.2637 · Cited by 438
Humphries, M. J., Komoriya, A., Akiyama, S. K., Olden, K., & Yamada, K. M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48327-5 · Cited by 347
New insights into form and function of fibronectin splice variants
White, E., Baralle, F., & Muro, A. (2008) · The Journal of Pathology · doi:10.1002/path.2388 · Cited by 323
Shimatsu, A., & Rotwein, P. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47652-1 · Cited by 278
Metadata
- Authors
- Tamkun, J. W., Schwarzbauer, J. E., & Hynes, R. O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-08
- Volume
- 81
- Issue
- 16
- Pages
- 5140-5144
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2027553466
- Cited by
- 163
- References
- 0
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon. https://app.cochat.ai/papers/10.1073/pnas.81.16.5140
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- Tamkun, J. W., Schwarzbauer, J. E., & Hynes, R. O. (1984). A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.16.5140
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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