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Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.
Open accessAbstract
The present studies demonstrate that both T-cell-derived supernatants containing B-cell growth factor (BCGF or BSF) and a partially purified preparation of the B-cell growth factor (BSF-p1) induce an increase in the expression of IA and IE-encoded antigens on small resting B cells. This increase is detectable by 6-8 hr after initiation of culture and is relatively selective, since levels of surface immunoglobulin and H-2 antigens do not increase to the same extent. Although interferon-gamma induces increased expression of Ia antigens on macrophages and dividing neoplastic B cells, it does not induce an increase in the expression of Ia antigens on resting B cells. These results demonstrate that BSF-p1 may play two roles: (i) it acts on resting B cells to increase the levels of Ia antigen expression; and (ii) it sustains the growth of B cells that have been previously activated with mitogens, antigens, or anti-Ig.
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Metadata
- Authors
- Noelle, R., Krammer, P. H., Ohara, J., Uhr, J. W., & Vitetta, E. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-10
- Volume
- 81
- Issue
- 19
- Pages
- 6149-6153
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026538540
- Cited by
- 435
- References
- 0
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Noelle, R., Krammer, P. H., Ohara, J., Uhr, J. W., & Vitetta, E. S. (1984). Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.19.6149
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