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Cited by 383

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U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear antigen 2.

Open access
Dambaugh, T, Hennessy, K, Chamnankit, L, Kieff, E·1984·Proceedings of the National Academy of Sciences

Abstract

Sequence analysis of the U2 regions of the B95-8 and AG876 Epstein-Barr virus (EBV) isolates reveals divergence within a long open reading frame previously identified as encoding 1.5 kilobases of the 3' end of a viral RNA expressed in latently infected, growth-transformed, B-lymphocyte cell lines. Differences among EBV isolates within the U2 open reading frame are shown to correlate with differences in an EBV nuclear antigen, EBNA2. B95-8, W91, Raji, Cherry, and Lamont EBV isolates have similar U2 domains and encode similar-size EBNA2 proteins, while AG876, Jijoye, and P3HR-1 have variant or absent U2 domains and variant or absent EBNA2 proteins. The AG876 U2 open reading frame and EBNA2 protein are both shorter than those of B95-8. These data indicate that the U2 open reading frame encodes EBNA2.

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Metadata

Authors
Dambaugh, T., Hennessy, K., Chamnankit, L., & Kieff, E.
Venue
Proceedings of the National Academy of Sciences
Published
1984-12
Volume
81
Issue
23
Pages
7632-7636
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2021464282
Cited by
383
References
1
FWCI
9.12
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear antigen 2. https://app.cochat.ai/papers/10.1073/pnas.81.23.7632
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Dambaugh, T., Hennessy, K., Chamnankit, L., & Kieff, E. (1984). U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear antigen 2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.23.7632

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