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DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.
Open accessAbstract
A temperature-sensitive DNA topoisomerase II mutant of the yeast Saccharomyces cerevisiae has been identified. Genetic analysis shows that a single recessive nuclear mutation is responsible for both temperature-sensitive growth and enzymatic activity. Thus, topoisomerase II is essential for viability and the mutation is most probably in the structural gene. Experiments with synchronized mutant cells show that at the nonpermissive temperature cells can undergo one, and only one, round of DNA replication. These cells are arrested at medial nuclear division. Analysis of 2-microns plasmid DNA from these cells shows it to be in the form of multiply intertwined catenated dimers. The results suggest that DNA topoisomerase II is necessary for the segregation of chromosomes at the termination of DNA replication.
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Citations
Cited by
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120
Nasmyth, K. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091334 · Cited by 805
Gangloff, S., McDonald, J. P., Bendixen, C., Arthur, L., & Rothstein, R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8391 · Cited by 677
New topoisomerase essential for chromosome segregation in E. coli
Kato, J.-I., Nishimura, Y., Imamura, R., Niki, H., Hiraga, S., & Suzuki, H. (1990) · Cell · doi:10.1016/0092-8674(90)90172-b · Cited by 566
The cohesin complex and its roles in chromosome biology
Peters, J.-M., Tedeschi, A., & Schmitz, J. (2008) · Genes & Development · doi:10.1101/gad.1724308 · Cited by 532
Metadata
- Authors
- DiNardo, S., Voelkel, K., & Sternglanz, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-05
- Volume
- 81
- Issue
- 9
- Pages
- 2616-2620
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2058911936
- Cited by
- 674
- References
- 0
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication. https://app.cochat.ai/papers/10.1073/pnas.81.9.2616
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- DiNardo, S., Voelkel, K., & Sternglanz, R. (1984). DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.9.2616
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