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Dimeric structure of single chloride channels from Torpedo electroplax.
Open accessAbstract
The inhibition by 4,4'-diisothiocyano-2,2'-stilbenedisulfonate (DIDS) of Cl- channels from Torpedo electroplax incorporated in planar phospholipid bilayer membranes is studied. DIDS irreversibly and rapidly inhibits the macroscopic conductance of membranes containing many channels. At the single-channel level, the effect of DIDS is more complicated. The uninhibited single channel displays three "substates" of conductances 20, 10, and 0 pS. Short exposure (5-30 s) to 10 microM DIDS converts this three-level active channel into a "conventional" channel of 10-pS conductance. Longer exposure eliminates all channel fluctuations. The results are taken as strong evidence that the Cl- channel is constructed as a functional dimer of identical protein subunits.
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Cited by
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
Dutzler, R., Campbell, E. B., Cadene, M., Chait, B. T., & MacKinnon, R. (2002) · Nature · doi:10.1038/415287a · Cited by 1,446
Molecular Structure and Physiological Function of Chloride Channels
Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle
Feng, L., Campbell, E. B., Hsiung, Y., & MacKinnon, R. (2010) · Science · doi:10.1126/science.1195230 · Cited by 270
Structure of a CLC chloride ion channel by cryo-electron microscopy
Park, E., Campbell, E. B., & MacKinnon, R. (2017) · Nature · doi:10.1038/nature20812 · Cited by 164
Pores Formed by Single Subunits in Mixed Dimers of Different CLC Chloride Channels
Weinreich, F., & Jentsch, T. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005733200 · Cited by 131
Metadata
- Authors
- Miller, C., & White, M. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-05
- Volume
- 81
- Issue
- 9
- Pages
- 2772-2775
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2059610950
- Cited by
- 257
- References
- 0
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Miller, C., & White, M. M. (1984). Dimeric structure of single chloride channels from Torpedo electroplax. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.9.2772
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