The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Specific protein binding to far upstream activating sequences in polymerase II promoters.
Open accessAbstract
A binding activity specific for the upstream activating sequence of the GAL1-GAL10 promoter of Saccharomyces cerevisiae has been purified 220-fold on the basis of a nitrocellulose filter-binding assay. The binding activity is enriched in a nuclear preparation and is likely to be the GAL4 gene product. DNase I-protection mapping patterns reveal binding to two 30-base-pair regions at the boundaries of the sequence. A nearly identical mapping pattern is obtained with the coordinately regulated GAL7 promoter. The four 30-base-pair regions of binding in the two promoters are closely homologous, with a core consensus sequence of C-G-CG-TG-C-A-A-C-A-G-T-G-C-T-C-C-G-A-A- GC-G-A-T. A synthetic oligonucleotide with such a sequence competes with the upstream activating sequence in the binding reaction.
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Dynan, W. S., & Tjian, R. (1983) · Cell · doi:10.1016/0092-8674(83)90210-6 · Cited by 1,445
Cited by
A structural taxonomy of DNA-binding domains
Harrison, S. C. (1991) · Nature · doi:10.1038/353715a0 · Cited by 608
Metadata
- Authors
- Bram, R. J., & Kornberg, R. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-01
- Volume
- 82
- Issue
- 1
- Pages
- 43-47
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049481106
- Cited by
- 234
- References
- 1
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Bram, R. J., & Kornberg, R. D. (1985). Specific protein binding to far upstream activating sequences in polymerase II promoters. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.1.43
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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