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Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene.
Open accessAbstract
The entire nucleotide sequence of an infectious clone of human T-cell leukemia virus type II provirus was determined. This provirus consists of 8952 nucleotides. In addition to long terminal repeats and gag, pol, env, and X, a protease gene that is responsible for processing the gag precursor protein was found. The protease gene is encoded in a different frame from gag and pol and was located between the gag and pol open reading frames. The 5' region of the protease gene overlaps the 3' gag region. Coding regions of the provirus show about 60% homology with those of human T-cell leukemia virus type I at the nucleotide level. The evolutionary relationship between human T-cell leukemia virus types I and II is discussed.
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Cites
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Cited by
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RNA pseudoknots: translational frameshifting and readthrough on viral RNAs
Ten Dam, E. B., Pleij, C. W. A., & Bosch, L. (1990) · Virus Genes · doi:10.1007/bf00678404 · Cited by 214
Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation
Cann, A. J., Rosenblatt, J. D., Wachsman, W., Shah, N. P., & Chen, I. S. Y. (1985) · Nature · doi:10.1038/318571a0 · Cited by 208
Self-citationKanaya, S., Kohara, A., Miura, Y., Sekiguchi, A., Iwai, S., Inoue, H., Ohtsuka, E., & Ikehara, M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39607-3 · Cited by 180
HTLV Tax: A Fascinating Multifunctional Co-Regulator of Viral and Cellular Pathways
Currer, R., Van Duyne, R., Jaworski, E., Guendel, I., Sampey, G., Das, R., Narayanan, A., & Kashanchi, F. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00406 · Cited by 156
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Metadata
- Authors
- Shimotohno, K., Takahashi, Y., Shimizu, N., Gojobori, T., Golde, D. W., Chen, I. S., Miwa, M., & Sugimura, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-05
- Volume
- 82
- Issue
- 10
- Pages
- 3101-3105
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052857807
- Cited by
- 379
- References
- 1
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- green
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