The DOI matches its Crossref record.
Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes.
Open accessAbstract
The five alpha genes of herpes simplex virus 1 are the first set of genes to be expressed after infection. Previous studies have shown that alpha genes resident in eukaryotic cells are induced by infection with herpes simplex virus 1 or 2 but not by other herpesviruses and indicate that the alpha trans-inducing factor was a structural component of the virion. This factor induces genes linked to a bona fide promoter and containing at the 5' end a small sequence derived from the promoter-regulatory domains of alpha genes. We report the sequence of a small DNA fragment shown previously to be capable of expressing the alpha trans-inducing factor in transient expression systems. The only gene encoded in its entirety in this fragment is predicted to specify a 479 amino acid protein with a Mr of 53,053. The precise termini of the 1.74-kilobase mRNA specifying this protein were determined in our 5' and 3' S1 nuclease protection studies.
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Cited by
Structure-Based Design of Transcription Factors
Pomerantz, J. L., Sharp, P. A., & Pabo, C. O. (1995) · Science · doi:10.1126/science.7809612 · Cited by 226
Metadata
- Authors
- Pellett, P. E., McKnight, J. L., Jenkins, F. J., & Roizman, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-09
- Volume
- 82
- Issue
- 17
- Pages
- 5870-5874
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2007022183
- Cited by
- 162
- References
- 0
- FWCI
- 13.06
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes. https://app.cochat.ai/papers/10.1073/pnas.82.17.5870
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- Pellett, P. E., McKnight, J. L., Jenkins, F. J., & Roizman, B. (1985). Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.17.5870
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