The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Priming of human mitochondrial DNA replication occurs at the light-strand promoter.
Open accessAbstract
Individual promoters for transcription of each strand of human mtDNA are located near the origin of heavy-strand DNA replication in the displacement-loop region. Initiation of heavy-strand synthesis represents the first event in mtDNA replication. Analyses of the 5' and 3' map positions of displacement-loop nucleic acids from mitochondria of cultured human cells reveal a close correspondence between the 3' ends of RNA, whose 5' ends map at a unique site, and the 5' ends of DNA strands. The 5' ends of the RNA species all map at nucleotide position 407 in the genomic sequence, which corresponds exactly to the major 5' transcriptional start site, determined previously in vitro, that is contained within the light-strand promoter sequence. Displacement-loop heavy-strand DNAs map immediately adjacent to the 3' termini of these RNAs, and these transition points between RNA and DNA lie within short conserved sequence blocks in the template sequence. The simplest interpretation of these data is that replication is initiated at the major transcriptional promoter with subsequent precise cleavage of primary transcripts to provide the appropriate primer species.
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Cites
Sequence and organization of the human mitochondrial genome
Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,636
Replication of animal mitochondrial DNA
Clayton, D. A. (1982) · Cell · doi:10.1016/0092-8674(82)90049-6 · Cited by 1,226
Self-citationTRANSCRIPTION OF THE MAMMALIAN MITOCHONDRIAL GENOME
Clayton, D. A. (1984) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.53.070184.003041 · Cited by 448
Self-citationSequence and properties of the human KB cell and mouse L cell D-loop regions of mitochondrial DNA
Walberg, M. W., & Clayton, D. A. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.20.5411 · Cited by 354
Self-citationMontoya, J., Christianson, T., Levens, D., Rabinowitz, M., & Attardi, G. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.23.7195 · Cited by 307
Chang, D. D., & Clayton, D. A. (1984) · Cell · doi:10.1016/0092-8674(84)90343-x · Cited by 282
Self-citationTapper, D. P., & Clayton, D. A. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69373-7 · Cited by 131
Self-citationWalberg, M. W., & Clayton, D. A. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33188-0 · Cited by 91
Self-citation[40] Isolation of mammalian mitochondrial DNA and RNA and cloning of the mitochondrial genome
Tapper, D. P., Etten, R. A. V., & Clayton, D. A. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)97153-7 · Cited by 81
Self-citationOjala, D., Crews, S. T., Montoya, J., Gelfand, R., & Attardi, G. M. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90454-x · Cited by 69
Cited by
The mitochondrial genome: structure, transcription, translation and replication
Taanman, J.-W. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00161-3 · Cited by 1,635
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666
MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES
Shadel, G. S., & Clayton, D. A. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.409 · Cited by 1,065
Self-citationA Direct Repeat Is a Hotspot for Large-Scale Deletion of Human Mitochondrial DNA
Schon, E. A., Rizzuto, R., Moraes, C. T., Nakase, H., Zeviani, M., & DiMauro, S. (1989) · Science · doi:10.1126/science.2711184 · Cited by 567
The Mitochondrial Genome of Animals
Brown, W. M. (1985) · Molecular Evolutionary Genetics · doi:10.1007/978-1-4684-4988-4_2 · Cited by 548
Metadata
- Authors
- Chang, D. D., & Clayton, D. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-01
- Volume
- 82
- Issue
- 2
- Pages
- 351-355
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2011073385
- Cited by
- 340
- References
- 13
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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