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T-cell antigenic sites tend to be amphipathic structures.
Open accessAbstract
We propose, on the basis of physical chemical and biological requirements for T-cell activation by antigen, that sites on a protein that can stimulate T lymphocytes will be capable of forming a stable amphipathic structure (i.e., one with separated hydrophobic and hydrophilic surfaces), displaying periodicity in hydrophobic residues. A spectral analysis of the 12 antigenic sites to which the method could be applied indicates that the amphipathic periodicity hypothesis is valid for 10 of them, generally with reliabilities that are well above 98%, with periodicities compatible with an alpha-helical structure. An 11th case manifests a different type of amphipathicity. The analyses require only a knowledge of amino acid sequence. The finding that T-cell antigenic sites show a high correlation with amphipathicity greatly simplifies the search for such sites and is potentially important for vaccine development.
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Cited by
Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature · doi:10.1038/329512a0 · Cited by 2,377
Dominance and Crypticity of T Cell Antigenic Determinants
Sercarz, E. (1993) · Annual Review of Immunology · doi:10.1146/annurev.immunol.11.1.729 · Cited by 855
Algorithms for the optimal identification of segment neighborhoods
Auger, I. E., & Lawrence, C. E. (1989) · Bulletin of Mathematical Biology · doi:10.1007/bf02458835 · Cited by 326
Metadata
- Authors
- DeLisi, C., & Berzofsky, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-10
- Volume
- 82
- Issue
- 20
- Pages
- 7048-7052
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2036463478
- Cited by
- 515
- References
- 0
- FWCI
- 17.94
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: T-cell antigenic sites tend to be amphipathic structures. https://app.cochat.ai/papers/10.1073/pnas.82.20.7048
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- DeLisi, C., & Berzofsky, J. A. (1985). T-cell antigenic sites tend to be amphipathic structures. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.20.7048
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