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The Ca channel in skeletal muscle is a large pore.
Open accessAbstract
The permeability of Ca channels to various foreign cations has been investigated in the absence of external Ca2+. All physiological metal cations are clearly permeant, including Mg2+. The large organic cation n-butylamine+ is sparingly permeant or impermeant, but its larger derivative 1,4-diaminobutane2+ is highly permeant. Among the cations of the methylated ammonium series, permeability diminishes in a graded fashion as ion size increases. Tetramethylammonium, the largest cation found to be permeant, has a diameter of about 6 A; hence, the aqueous pore of the Ca channel at its narrowest point can be no smaller. That the pore is so large strengthens our view that, under physiologic conditions, the high selectivity of Ca channels is due to selective binding of Ca2+ rather than to rejection of other cations by, for example, a sieving mechanism.
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Cited by
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Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
The mitochondrial calcium uniporter is a highly selective ion channel
Kirichok, Y., Krapivinsky, G., & Clapham, D. E. (2004) · Nature · doi:10.1038/nature02246 · Cited by 1,409
The crystal structure of a voltage-gated sodium channel
Payandeh, J., Scheuer, T., Zheng, N., & Catterall, W. A. (2011) · Nature · doi:10.1038/nature10238 · Cited by 1,429
Bormann, J., Hamill, O. P., & Sakmann, B. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016493 · Cited by 1,157
PERMEATION AND SELECTIVITY OF TRP CHANNELS
Owsianik, G., Talavera, K., Voets, T., & Nilius, B. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.101406 · Cited by 558
Metadata
- Authors
- McCleskey, E. W., & Almers, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-10
- Volume
- 82
- Issue
- 20
- Pages
- 7149-7153
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1970288191
- Cited by
- 218
- References
- 0
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- green
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- McCleskey, E. W., & Almers, W. (1985). The Ca channel in skeletal muscle is a large pore. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.20.7149
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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