Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man.

White, P C; Grossberger, D; Onufer, B J; Chaplin, D D; New, M I; Dupont, B; Strominger, J L

doi:10.1073/pnas.82.4.1089

Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man.

Two genes encoding steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor: oxygen oxidoreductase (21-hydroxylating); EC 1.14.99.10], a cytochrome P-450 enzyme, have been located within the HLA major histocompatibility complex. Congenital adrenal hyperplasia due to 21-…