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Evolution and organization of the fibrinogen locus on chromosome 4: gene duplication accompanied by transposition and inversion.
Open accessAbstract
Human fibrinogen cDNA probes for the alpha-, beta-, and gamma-polypeptide chains have been used to isolate the corresponding genes from human genomic libraries. There is a single copy of each gene. Restriction endonuclease analysis of isolated genomic clones and human genomic DNA indicates that the human alpha-, beta-, and gamma-fibrinogen genes are closely linked in a 50-kilobase region of a single human chromosome: the alpha-gene in the middle flanked by the beta-gene on one side and the gamma-gene on the other. The alpha- and gamma-chain genes are oriented in tandem and transcribed toward the beta-chain gene. The beta-chain gene is transcribed from the opposite DNA strand toward the gamma- and alpha-chain genes. The three genes have been localized to the distal third of the long arm of chromosome 4, bands q23-q32, by in situ hybridization with fibrinogen cDNAs and by examination of DNA from multiple rodent-human somatic cell hybrids. Alternative explanations for the present arrangement of the three fibrinogen genes involve either a three-step mechanism with inversion of the alpha/gamma-region or a two-step mechanism involving remote transposition and inversion. The second more simple mechanism has a precedent in the origin of repeated regions of the fibrinogen and immunoglobulin genes.
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Cited by
The molecular basis of blood coagulation
Furie, B., & Furie, B. C. (1988) · Cell · doi:10.1016/0092-8674(88)90567-3 · Cited by 1,247
Weisel, J. W. (2005) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(05)70008-5 · Cited by 816
Fibrin Formation, Structure and Properties
Weisel, J. W., & Litvinov, R. I. (2017) · Subcellular Biochemistry · doi:10.1007/978-3-319-49674-0_13 · Cited by 729
Undas, A., & Ariëns, R. A. S. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.230631 · Cited by 526
Congenital Fibrinogen Disorders: An Update
Casini, A., Neerman-Arbez, M., & de Moerloose, P. (2013) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0033-1349222 · Cited by 302
Metadata
- Authors
- Kant, J. A., Fornace, A. J., Saxe, D., Simon, M. I., McBride, O. W., & Crabtree, G. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-04
- Volume
- 82
- Issue
- 8
- Pages
- 2344-2348
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2062923310
- Cited by
- 257
- References
- 0
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Kant, J. A., Fornace, A. J., Saxe, D., Simon, M. I., McBride, O. W., & Crabtree, G. R. (1985). Evolution and organization of the fibrinogen locus on chromosome 4: gene duplication accompanied by transposition and inversion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.8.2344
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