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Cited by 389

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Walking along the rabies genome: is the large G-L intergenic region a remnant gene?

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Tordo, N, Poch, O, Ermine, A, Keith, G, Rougeon, F·1986·Proceedings of the National Academy of Sciences

Abstract

Rabies cDNA clones, obtained by "walking along the genome" using two successive DNA primers, have allowed the sequence determination of the genes encoding the N, M1, M2, G, and the beginning of the L protein as well as the rabies intergenic regions. Start and stop transcription signals located at the border of each gene encoding a protein have been identified and are similar to the corresponding signals from vesicular stomatitis virus (VSV) and Sendai virus. Except for limited stretches of the nucleoprotein, there is no homology between corresponding structural proteins of these three viruses. Rabies intergenic regions are variable both in length and sequence. Evidence for the existence of a remnant protein gene in the 423 nucleotide long G-L intergenic region is presented. This finding is discussed in terms of the evolution of unsegmented negative-strand RNA viruses.

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Metadata

Authors
Tordo, N., Poch, O., Ermine, A., Keith, G., & Rougeon, F.
Venue
Proceedings of the National Academy of Sciences
Published
1986-06
Volume
83
Issue
11
Pages
3914-3918
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2078029046
Cited by
389
References
1
FWCI
1.89
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Walking along the rabies genome: is the large G-L intergenic region a remnant gene? https://app.cochat.ai/papers/10.1073/pnas.83.11.3914
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Tordo, N., Poch, O., Ermine, A., Keith, G., & Rougeon, F. (1986). Walking along the rabies genome: is the large G-L intergenic region a remnant gene? Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.11.3914

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