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Cited by 559

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Covalent modification of the glnG product, NRI, by the glnL product, NRII, regulates the transcription of the glnALG operon in Escherichia coli.

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Ninfa, A J, Magasanik, B·1986·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.83.16.5909
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Abstract

Transcription from nitrogen-regulated promoters, such as glnAp2, requires the glnG gene product, NRI, as well as the rpoN(glnF) gene product, sigma60, and is regulated by the glnL gene product, NRII. We find that in a reaction mixture containing NRI, NRII, and ATP, NRII catalyzes the transfer of the gamma phosphate of ATP to NRI. This covalent modification of NRI occurs concurrently with the acquisition of the ability by the reaction mixture to activate transcription from glnAp2. In the presence of PII, the product of glnB, NRII catalyzes the removal of the phosphate from NRI-phosphate. This reaction occurs concurrently with the loss by the reaction mixture of the ability to activate transcription from glnAp2. On the basis of this evidence, we propose that NRI-phosphate activates transcription from nitrogen-regulated promoters and that the role of NRII is control of the formation and breakdown of NRI-phosphate in response to cellular signals of nitrogen availability.

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Metadata

Authors
Ninfa, A. J., & Magasanik, B.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1986-08
Volume
83
Issue
16
Pages
5909-5913
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.83.16.5909
OpenAlex
W1965844459
Cited by
559
References
10
FWCI
31.13
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Covalent modification of the glnG product, NRI, by the glnL product, NRII, regulates the transcription of the glnALG operon in Escherichia coli. https://app.cochat.ai/papers/10.1073/pnas.83.16.5909
The paper
Ninfa, A. J., & Magasanik, B. (1986). Covalent modification of the glnG product, NRI, by the glnL product, NRII, regulates the transcription of the glnALG operon in Escherichia coli. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.16.5909

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.