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Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins.
Open accessAbstract
Antisera were raised against purified subunits of regulatory GTP-binding proteins (G proteins) and against synthetic peptides that correspond to defined regions of G proteins. Peptide antisera were generated that recognized all alpha or all beta subunits from Gs, Gi, Go, and transducin; others recognized only Gs alpha or Go alpha. Such cross-reaction or complete specificity for a given alpha subunit was not obtained when purified subunits were injected. Peptide antisera were used to identify G protein subunits in selected tissue membrane preparations by immunoblots.
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Citations
Cited by
Tam, J. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5409 · Cited by 1,251
Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins
Taylor, S. J., Chae, H. Z., Rhee, S. G., & Exton, J. H. (1991) · Nature · doi:10.1038/350516a0 · Cited by 780
Cloning and expression of a widely distributed (type IV) adenylyl cyclase.
Gao, B. N., & Gilman, A. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10178 · Cited by 365
Self-citationGutowski, S., Smrcka, A., Nowak, L., Wu, D. G., Simon, M., & Sternweis, P. C. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54955-3 · Cited by 324
Regulation of purified type I and type II adenylylcyclases by G protein beta gamma subunits.
Taussig, R., Quarmby, L. M., & Gilman, A. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54106-5 · Cited by 296
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Metadata
- Authors
- Mumby, S. M., Kahn, R. A., Manning, D. R., & Gilman, A. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-01
- Volume
- 83
- Issue
- 2
- Pages
- 265-269
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2032941398
- Cited by
- 379
- References
- 0
- FWCI
- 18.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mumby, S. M., Kahn, R. A., Manning, D. R., & Gilman, A. G. (1986). Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.2.265
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
