The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae.
Open accessAbstract
A gene, PDE2, has been cloned from the yeast Saccharomyces cerevisiae that, when present in high copy, reverses the phenotypic effects of RAS2Val19, a mutant form of the RAS2 gene that renders yeast cells sensitive to heat shock and starvation. It has previously been shown that the RAS proteins are potent activators of yeast adenylate cyclase. We report here that PDE2 encodes a high-affinity cAMP phosphodiesterase that shares sequence homology with animal cell phosphodiesterases. These results therefore imply that the effects of RAS2Val19 are mediated through its changes in cAMP concentration.
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Mechanism of activation of a human oncogene
Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393
Cited by
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.
Ballester, R., Marchuk, D., Boguski, M., Saulino, A., Letcher, R., Wigler, M., & Collins, F. (1990) · Cell · doi:10.1016/0092-8674(90)90151-4 · Cited by 847
Self-citationThe S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S., & Wigler, M. (1987) · Cell · doi:10.1016/0092-8674(87)90076-6 · Cited by 477
Self-citationPan, X., & Heitman, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4874 · Cited by 349
Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
Peeters, K., Van Leemputte, F., Fischer, B., Bonini, B. M., Quezada, H., Tsytlonok, M., Haesen, D., Vanthienen, W., Bernardes, N., Gonzalez-Blas, C. B., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01019-z · Cited by 203
Deconstruction of the Ras switching cycle through saturation mutagenesis
Bandaru, P., Shah, N. H., Bhattacharyya, M., Barton, J. P., Kondo, Y., Cofsky, J. C., Gee, C. L., Chakraborty, A. K., Kortemme, T., Ranganathan, R., et al. (2017) · eLife · doi:10.7554/elife.27810 · Cited by 117
“Once the cells reached the desired OD, 1 mL of each culture was subject to heat shock at 55˚C for 5 min, as described (Sass et al., 1986).”
BackgroundMethodInfluential
Metadata
- Authors
- Sass, P., Field, J., Nikawa, J., Toda, T., & Wigler, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-12
- Volume
- 83
- Issue
- 24
- Pages
- 9303-9307
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1974605099
- Cited by
- 288
- References
- 1
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sass, P., Field, J., Nikawa, J., Toda, T., & Wigler, M. (1986). Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.24.9303
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