The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.
Open accessAbstract
Transin RNA is a 1.9-kilobase RNA transcript induced by oncogenes in rat embryo fibroblast cell lines. We show that RNA species complementary to a cloned transin cDNA are present in mouse skin squamous cell carcinomas induced by a classical initiation-promotion protocol but not in premalignant, benign papillomas or in normal epidermis. A single application of a tumor promoting phorbol ester to normal epidermis elicits a transient increase in these RNA levels. Transin RNA encodes a secreted protease, an activity consistent with a functional role for enhanced expression of transin RNA in the progression of benign, encapsulated tumors to malignant, invasive carcinomas.
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Citations
Cites
Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas
Balmain, A., Ramsden, M., Bowden, G. T., & Smith, J. (1984) · Nature · doi:10.1038/307658a0 · Cited by 529
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Cited by
Collier, I. E., Wilhelm, S. M., Eisen, A. Z., Marmer, B. L., Grant, G. A., Seltzer, J. L., Kronberger, A., He, C. S., Bauer, E. A., & Goldberg, G. I. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68680-6 · Cited by 1,044
Transforming Growth Factor‐β: Major Role in Regulation of Extracellular Matrix
ROBERTS, A. B., HEINE, U. I., FLANDERS, K. C., & SPORN, M. B. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17931.x · Cited by 696
Torre-Amione, G., Beauchamp, R. D., Koeppen, H., Park, B. H., Schreiber, H., Moses, H. L., & Rowley, D. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1486 · Cited by 403
Wasylyk, C., Gutman, A., Nicholson, R., & Wasylyk, B. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08053.x · Cited by 368
The collagenase gene family in humans consists of at least four members
Muller, D., Quantin, B., Gesnel, M. C., Millon-Collard, R., Abecassis, J., & Breathnach, R. (1988) · Biochemical Journal · doi:10.1042/bj2530187 · Cited by 365
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Metadata
- Authors
- Matrisian, L. M., Bowden, G. T., Krieg, P., Fürstenberger, G., Briand, J. P., Leroy, P., & Breathnach, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-12
- Volume
- 83
- Issue
- 24
- Pages
- 9413-9417
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2022676856
- Cited by
- 255
- References
- 1
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Matrisian, L. M., Bowden, G. T., Krieg, P., Fürstenberger, G., Briand, J. P., Leroy, P., & Breathnach, R. (1986). The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.24.9413
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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