The DOI matches its Crossref record.
Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.
Open accessAbstract
We propose that a fundamental problem in the faithful replication of complex chromosomes of higher eukaryotes is the proper control of both the number and timing of the multiple initiations of replication on single chromosomes. When replication patterns are disrupted by any of a variety of agents, overreplication of DNA can occur. We propose a model that accounts for the generation of a wide variety of chromosomal aberrations-rearrangements, resulting from the various ways in which the overreplicated strands can undergo recombination. We also discuss certain implications of the generation of chromosomal alterations in higher eukaryotes as they may relate to cancer chemotherapy, cancer progression, aging, and rapid speciation-evolution.
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Citations
Cited by
Evolution of chromosome bands: molecular ecology of noncoding DNA
Holmquist, G. P. (1989) · Journal of Molecular Evolution · doi:10.1007/bf02602928 · Cited by 177
Isolation and analysis of rereplicated DNA by Rerep-Seq
Menzel, J., Tatman, P., & Black, J. C. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa197 · Cited by 126
Metadata
- Authors
- Schimke, R. T., Sherwood, S. W., Hill, A. B., & Johnston, R. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-04
- Volume
- 83
- Issue
- 7
- Pages
- 2157-2161
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2045652766
- Cited by
- 232
- References
- 0
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications. https://app.cochat.ai/papers/10.1073/pnas.83.7.2157
- The paper
- Schimke, R. T., Sherwood, S. W., Hill, A. B., & Johnston, R. N. (1986). Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.7.2157
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
