The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Firefly luciferase is targeted to peroxisomes in mammalian cells.
Open accessAbstract
Although several enzymes known to reside in peroxisomes have been studied extensively, no cis-acting amino acid sequences involved in the transport of these proteins to peroxisomes have been described. As a first step towards the determination of a putative peroxisomal targeting sequence, we have expressed the cDNA encoding the firefly luciferase [Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolyzing), EC 1.13.12.7] in monkey kidney cells and found that the product of the gene is transported to peroxisomes. Luciferase is derived from the firefly (Photinus pyralis) and is synthesized and stored in the cells of the firefly's lantern organ, where it is also found in peroxisomes. The fact that this protein is similarly targeted in cells from such different organisms suggests that the process of protein transport to peroxisomes has been highly conserved through evolution.
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Cites
Peroxisomes (microbodies and related particles).
De Duve, C., & Baudhuin, P. (1966) · Physiological Reviews · doi:10.1152/physrev.1966.46.2.323 · Cited by 1,666
Cited by
Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells.
Crapo, J. D., Oury, T., Rabouille, C., Slot, J. W., & Chang, L. Y. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10405 · Cited by 503
Gould, S. J., Keller, G. A., & Subramani, S. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.3.897 · Cited by 337
Self-citationLipofection of cDNAs in the embryonic vertebrate central nervous system
Holt, C. E., Garlick, N., & Cornel, E. (1990) · Neuron · doi:10.1016/0896-6273(90)90095-w · Cited by 262
Wiemer, E. A. C., Wenzel, T., Deerinck, T. J., Ellisman, M. H., & Subramani, S. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.1.71 · Cited by 156
Self-citationNetik, A., Forss-Petter, S., Holzinger, A., Molzer, B., Unterrainer, G., & Berger, J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.5.907 · Cited by 148
Metadata
- Authors
- Keller, G. A., Gould, S., Deluca, M., & Subramani, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-05
- Volume
- 84
- Issue
- 10
- Pages
- 3264-3268
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060417593
- Cited by
- 188
- References
- 1
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Keller, G. A., Gould, S., Deluca, M., & Subramani, S. (1987). Firefly luciferase is targeted to peroxisomes in mammalian cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.10.3264
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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