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Tenascin is a stromal marker for epithelial malignancy in the mammary gland.
Open accessAbstract
Tenascin is an extracellular matrix glycoprotein that is not present in the normal mature rat mammary gland. The distribution of tenascin was examined by immunohistochemistry in mammary tumors from carcinogen-treated and untreated rats, in virus-induced mammary tumors from mice, and in a variety of mammary gland lesions from humans. Tenascin was detectable in the stroma of the malignant but not of the benign tumors from all species. An inhibition ELISA, testing homogenates of rat tumors, confirmed that tenascin was present in malignant but not in benign tumors. Thus, tenascin was consistently found to be a stromal marker for epithelial malignancy in the mammary gland. It is concluded that tenascin may be involved in the interactions between the epithelial and mesenchyme-derived (stromal) components of the mammary gland, which are known to influence epithelial carcinogenesis in this organ.
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Grumet, M., Hoffman, S., Crossin, K. L., & Edelman, G. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.8075 · Cited by 391
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TUMOR STROMA AND REGULATION OF CANCER DEVELOPMENT
Tlsty, T. D., & Coussens, L. M. (2006) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100224 · Cited by 987
Kojima, Y., Acar, A., Eaton, E. N., Mellody, K. T., Scheel, C., Ben-Porath, I., Onder, T. T., Wang, Z. C., Richardson, A. L., Weinberg, R. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013805107 · Cited by 848
Metadata
- Authors
- Mackie, E. J., Chiquet-Ehrismann, R., Pearson, C. A., Inaguma, Y., Taya, K., Kawarada, Y., & Sakakura, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-07
- Volume
- 84
- Issue
- 13
- Pages
- 4621-4625
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2039374288
- Cited by
- 272
- References
- 1
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Mackie, E. J., Chiquet-Ehrismann, R., Pearson, C. A., Inaguma, Y., Taya, K., Kawarada, Y., & Sakakura, T. (1987). Tenascin is a stromal marker for epithelial malignancy in the mammary gland. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.13.4621
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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