The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis.
Open accessAbstract
Inhibin, a gonadal hormone capable of preferential suppression of pituitary follicle-stimulating hormone (FSH) secretion, has recently been purified. The major form of this protein is an alpha beta heterodimer encoded by two separate genes. In contrast to the FSH-suppressing action of the alpha beta heterodimer, the beta beta homodimer stimulates FSH secretion. Luteinizing hormone (LH)-secreting pituitary cells and gonadal androgen-producing cells have long been shown to form a closed-loop feedback axis. Based on recent studies demonstrating the FSH stimulation of inhibin biosynthesis by ovarian granulosa and testis Sertoli cells, an additional closed-loop feedback axis exists between pituitary FSH- and gonadal inhibin-producing cells. Because uncharacterized Sertoli cell factors have been suggested to either stimulate or inhibit androgen production by testicular Leydig cells, we have tested the intragonadal paracrine actions of heterodimers and homodimers of inhibin subunits. In primary cultures of testis cells, the alpha beta heterodimer of inhibin enhances Leydig cell androgen biosynthesis stimulated by LH, whereas the beta beta homodimer suppresses androgen production. Furthermore, similar modulatory actions of inhibin-related proteins were found in cultured ovarian theca-interstitial cells and theca explants treated with LH. In contrast, treatment with the inhibin-related proteins alone did not affect gonadal steroidogenesis. Our data indicate that the inhibin-related gene products synthesized by Sertoli and granulosa cells may form heterodimers or homodimers to serve as intragonadal paracrine signals in the modulation of LH-stimulated androgen biosynthesis and allow cross-communication between the two feedback loops.
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Cites
Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid
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Self-citationPituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin
Ling, N., Ying, S.-Y., Ueno, N., Shimasaki, S., Esch, F., Hotta, M., & Guillemin, R. (1986) · Nature · doi:10.1038/321779a0 · Cited by 1,081
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Isolation of inhibin from bovine follicular fluid
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Dual Endocrine Activity of the Testes
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Isolation of porcine follicular fluid inhibin of 32K daltons
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Cited by
PLATELET-DERIVED GROWTH FACTOR
Ross, R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92760-8 · Cited by 940
α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice
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Self-citationOvarian antral folliculogenesis during the human menstrual cycle: A review
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Metadata
- Authors
- Hsueh, A. J., Dahl, K. D., Vaughan, J., Tucker, E., Rivier, J., Bardin, C. W., & Vale, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-07
- Volume
- 84
- Issue
- 14
- Pages
- 5082-5086
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2015463509
- Cited by
- 422
- References
- 27
- FWCI
- 23.95
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis. https://app.cochat.ai/papers/10.1073/pnas.84.14.5082
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- Hsueh, A. J., Dahl, K. D., Vaughan, J., Tucker, E., Rivier, J., Bardin, C. W., & Vale, W. (1987). Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.14.5082
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