The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.
Open accessAbstract
We isolated overlapping cDNA clones corresponding to the major MET protooncogene transcript. The cDNA nucleotide sequence contained an open reading frame of 1408 amino acids with features characteristic of the tyrosine kinase family of growth factor receptors. These features include a putative 24-amino acid signal peptide and a candidate, hybrophobic, membrane-spanning segment of 23 amino acids, which defines an extracellular domain of 926 amino acids that could serve as a ligand-binding domain. A putative intracellular domain 435 amino acids long shows high homology with the SRC family of tyrosine kinases and within the kinase domain is most homologous with the human insulin receptor (44%) and v-abl (41%). Despite these similarities, however, we found no apparent sequence homology to other growth factor receptors in the putative ligand-binding domain. We conclude from these results that the MET protooncogene is a cell-surface receptor for an as-yet-unknown ligand.
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Citations
Cites
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
Klein, A. D., Kessel, A. G. V., Grosveld, G., Bartram, C. R., Hagemeijer, A., Bootsma, D., Spurr, N. K., Heisterkamp, N., Groffen, J., & Stephenson, J. R. (1982) · Nature · doi:10.1038/300765a0 · Cited by 1,378
Cited by
Bean, J., Brennan, C., Shih, J.-Y., Riely, G., Viale, A., Wang, L., Chitale, D., Motoi, N., Szoke, J., Broderick, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710370104 · Cited by 1,598
Wilks, A. F., Harpur, A. G., Kurban, R. R., Ralph, S. J., Zürcher, G., & Ziemiecki, A. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.4.2057 · Cited by 528
Tyrosine kinase receptor indistinguishable from the c-met protein
Giordano, S., Ponzetto, C., Renzo, M. F. D., Cooper, C. S., & Comoglio, P. M. (1989) · Nature · doi:10.1038/339155a0 · Cited by 490
Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction
Wilks, A. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1603 · Cited by 424
Cross-talk between Epidermal Growth Factor Receptor and c-Met Signal Pathways in Transformed Cells*
Jo, M., Stolz, D. B., Esplen, J. E., Dorko, K., Michalopoulos, G. K., & Strom, S. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8806 · Cited by 347
Metadata
- Authors
- Park, M., Dean, M., Kaul, K., Braun, M. J., Gonda, M. A., & Vande Woude, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-09
- Volume
- 84
- Issue
- 18
- Pages
- 6379-6383
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2003463361
- Cited by
- 561
- References
- 1
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Park, M., Dean, M., Kaul, K., Braun, M. J., Gonda, M. A., & Vande Woude, G. (1987). Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.18.6379
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