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Three-dimensional structure of a genetically engineered variant of porcine growth hormone.
Open accessAbstract
The three-dimensional structure of a genetically engineered variant of porcine growth hormone, methionyl porcine somatotropin (MPS), has been determined at 2.8-A resolution, using single crystal x-ray diffraction techniques. Phases were obtained by use of a single isomorphous K2OsCl6 derivative and were improved by use of the density modification procedure. The MPS structure is predominantly helical. It consists mainly of four antiparallel alpha-helices arranged in a left twisted helical bundle, a structural motif observed in a number of other unrelated proteins. However, the way the four helices are connected in the bundle is unusual and, to our knowledge, has never been reported before. Alignment of the amino acid sequence of MPS with that of other growth hormones reveals that residues within the alpha-helices are predominantly invariant and thus these invariant residues are necessary to maintain the structural integrity of these proteins.
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Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Cunningham, B. C., Ultsch, M., de Vos, A. M., Mulkerrin, M. G., Clauser, K. R., & Wells, J. A. (1991) · Science · doi:10.1126/science.1948064 · Cited by 874
Krantz, S. (1991) · Blood · doi:10.1182/blood.v77.3.419.419 · Cited by 855
Idzerda, R. L., March, C. J., Mosley, B., Lyman, S. D., Vanden Bos, T., Gimpel, S. D., Din, W. S., Grabstein, K. H., Widmer, M. B., & Park, L. S. (1990) · The Journal of experimental medicine · doi:10.1084/jem.171.3.861 · Cited by 420
GOFFIN, V., SHIVERICK, K. T., KELLY, P. A., & MARTIAL, J. A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-4-385 · Cited by 293
Metadata
- Authors
- Abdel-Meguid, S. S., Shieh, H. S., Smith, W. W., Dayringer, H. E., Violand, B. N., & Bentle, L. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-09
- Volume
- 84
- Issue
- 18
- Pages
- 6434-6437
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2168059460
- Cited by
- 458
- References
- 0
- FWCI
- 34.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Abdel-Meguid, S. S., Shieh, H. S., Smith, W. W., Dayringer, H. E., Violand, B. N., & Bentle, L. A. (1987). Three-dimensional structure of a genetically engineered variant of porcine growth hormone. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.18.6434
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