The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma.
Open accessAbstract
The genotypes were analyzed at 11 polymorphic DNA loci (restriction fragment length alleles) on chromosome 22 in tumor and normal tissue from 35 unrelated patients with meningiomas. Sixteen tumors retained the constitutional genotype along chromosome 22, while 14 tumors (40%) showed loss of one constitutional allele at all informative loci, consistent with monosomy 22 in the tumor DNA. The remaining 5 tumors (14%) showed loss of heterozygosity in the tumor DNA at one or more chromosome 22 loci and retained heterozygosity at other loci, consistent with variable terminal deletions of one chromosome 22 in the tumor DNA. The results suggest that a meningioma locus is located distal to the myoglobin locus, within 22q12.3-qter. Multiple loci on other chromosomes also were studied, and 12 of the 19 tumors with losses of chromosome 22 alleles showed additional losses of heterozygosity at loci on one to three other chromosomes. All tumors that retained the constitutional genotype on chromosome 22 also retained heterozygosity at all informative loci on other chromosomes analyzed, suggesting that the rearrangement of chromosome 22 is a primary event in the tumorigenesis of meningioma.
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Cites
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948
Cited by
Asthagiri, A. R., Parry, D. M., Butman, J. A., Kim, H. J., Tsilou, E. T., Zhuang, Z., & Lonser, R. R. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60259-2 · Cited by 665
Chromosome Aberrations and Cancer
Solomon, E., Borrow, J., & Goddard, A. D. (1991) · Science · doi:10.1126/science.1957167 · Cited by 584
Histological classification and molecular genetics of meningiomas
Riemenschneider, M. J., Perry, A., & Reifenberger, G. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70625-1 · Cited by 573
Ponder, B. (1988) · Nature · doi:10.1038/335400a0 · Cited by 277
LARGE2 facilitates the maturation of α-dystroglycan more effectively than LARGE
Fujimura, K., Sawaki, H., Sakai, T., Hiruma, T., Nakanishi, N., Sato, T., Ohkura, T., & Narimatsu, H. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.082 · Cited by 59
Metadata
- Authors
- Dumanski, J. P., Carlbom, E., Collins, V. P., & Nordenskjöld, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-12
- Volume
- 84
- Issue
- 24
- Pages
- 9275-9279
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2158510547
- Cited by
- 214
- References
- 1
- FWCI
- 13.84
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. https://app.cochat.ai/papers/10.1073/pnas.84.24.9275
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- Dumanski, J. P., Carlbom, E., Collins, V. P., & Nordenskjöld, M. (1987). Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.24.9275
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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