The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sequence of the cDNA encoding the laminin B1 chain reveals a multidomain protein containing cysteine-rich repeats.
Open accessAbstract
Laminin is a basement membrane-specific glycoprotein (800 kDa) consisting of three chains: A, B1, and B2. Laminin has diverse biological functions, which include stimulating epithelial cell growth and differentiation. We have isolated two overlapping cDNA clones that span 5.9 kilobases and code for the entire B1 chain of mouse laminin. The nucleotide sequence of the clones reveals a 5358-base pair open reading frame that potentially codes for 1786 amino acids, including 20 amino acids of a presumptive signal peptide. Analysis of the deduced protein sequence predicts that the B1 chain has seven distinct domains that include cysteine-rich repeats, alpha-helical, and globular structures. Part of the cysteine-rich region is homologous to epidermal growth factor and other proteins that contain epidermal growth factor-like repeats.
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Cites
Laminin–a glycoprotein from basement membranes
Timpl, R., Rohde, H., Robey, P. G., Rennard, S. I., Foidart, J. M., & Martin, G. R. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83607-4 · Cited by 2,378
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Cited by
MultiCoil: A program for predicting two‐and three‐stranded coiled coils
Wolf, E., Kim, P. S., & Berger, B. (1997) · Protein Science · doi:10.1002/pro.5560060606 · Cited by 720
Tenascin: cDNA cloning and induction by TGF-beta.
Pearson, C. A., Pearson, D., Shibahara, S., Hofsteenge, J., & Chiquet-Ehrismann, R. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03160.x · Cited by 451
Domains of laminin with growth-factor activity
Panayotou, G., End, P., Aumailley, M., Timpl, R., & Engel, J. (1989) · Cell · doi:10.1016/0092-8674(89)90987-2 · Cited by 341
Structure and function of epidermal growth factor‐like regions in proteins
Appella, E., Weber, I. T., & Blasi, F. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80690-2 · Cited by 309
Metadata
- Authors
- Sasaki, M., Kato, S., Kohno, K., Martin, G. R., & Yamada, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-02
- Volume
- 84
- Issue
- 4
- Pages
- 935-939
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2091970430
- Cited by
- 376
- References
- 1
- FWCI
- 14.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Sasaki, M., Kato, S., Kohno, K., Martin, G. R., & Yamada, Y. (1987). Sequence of the cDNA encoding the laminin B1 chain reveals a multidomain protein containing cysteine-rich repeats. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.4.935
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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