The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model.
Open accessAbstract
Recombinant human interleukin 2 purified from Escherichia coli has limited solubility at neutral pH and a short circulatory half-life. This recombinant interleukin 2 was chemically modified by an active ester of polyethylene glycol. The modified interleukin 2 was purified by hydrophobic interaction chromatography and characterized by sodium dodecyl sulfate/polyacrylamide gel electrophoresis and isoelectric focusing. This conjugate was compared to unmodified recombinant interleukin 2 in vitro and in vivo. Covalent attachment of the hydrophilic polymer polyethylene glycol enhanced the solubility of interleukin 2, decreased its plasma clearance, and increased its antitumor potency in the Meth A murine sarcoma model.
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Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
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(1991) · PubMed · Cited by 418
Yokoyama, M. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00115-6 · Cited by 308
Knauf, M. J., Bell, D. P., Hirtzer, P., Luo, Z. P., Young, J. D., & Katre, N. V. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68146-3 · Cited by 272
Self-citation(2019) · doi:10.1158/2159-8290.cd-18-1495 · Cited by 231
Metadata
- Authors
- Katre, N. V., Knauf, M. J., & Laird, W. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-03
- Volume
- 84
- Issue
- 6
- Pages
- 1487-1491
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977404966
- Cited by
- 244
- References
- 1
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model. https://app.cochat.ai/papers/10.1073/pnas.84.6.1487
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- Katre, N. V., Knauf, M. J., & Laird, W. J. (1987). Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.6.1487
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
