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A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes.
Open accessAbstract
Using gel retardation and in vitro "footprinting", we have analyzed the interactions between nuclear proteins derived from various mouse cells and the enhancer and interferon response sequences of the H-2Kb gene. We have found that a protein factor binds a site in the enhancer sequence that partially overlaps the interferon response sequence. This factor also binds to a similar sequence lying in the opposite orientation in the promoter of the mouse beta 2-microglobulin gene, suggesting a common regulatory mechanism. Transfection competition experiments indicate that this factor acts as a positive element in the expression of H-2 and beta 2-microglobulin genes.
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Citations
Cited by
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
Grilli, M., Chiu, J. J.-S., & Lenardo, M. J. (1993) · International Review of Cytology · doi:10.1016/s0074-7696(08)61873-2 · Cited by 936
Kieran, M., Blank, V., Logeat, F., Vandekerckhove, J., Lottspeich, F., Le Bail, O., Urban, M. B., Kourilsky, P., Baeuerle, P. A., & Israël, A. (1990) · Cell · doi:10.1016/0092-8674(90)90275-j · Cited by 874
Self-citationHTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor
Leung, K., & Nabel, G. J. (1988) · Nature · doi:10.1038/333776a0 · Cited by 586
Shimizu, H., Mitomo, K., Watanabe, T., Okamoto, S., & Yamamoto, K. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.2.561 · Cited by 375
Driggers, P. H., Ennist, D. L., Gleason, S. L., Mak, W. H., Marks, M. S., Levi, B. Z., Flanagan, J. R., Appella, E., & Ozato, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3743 · Cited by 356
Metadata
- Authors
- Israël, A., Kimura, A., Kieran, M., Yano, O., Kanellopoulos, J., Le Bail, O., & Kourilsky, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-05
- Volume
- 84
- Issue
- 9
- Pages
- 2653-2657
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2089926630
- Cited by
- 161
- References
- 0
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes. https://app.cochat.ai/papers/10.1073/pnas.84.9.2653
- The paper
- Israël, A., Kimura, A., Kieran, M., Yano, O., Kanellopoulos, J., Le Bail, O., & Kourilsky, P. (1987). A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.9.2653
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
