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3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.
Open accessAbstract
An excess of the tryptophan metabolite quinolinic acid in the brain has been hypothetically related to the pathogenesis of Huntington disease. Quinolinate's immediate biosynthetic enzyme, 3-hydroxyanthranilate oxygenase (EC 1.13.11.6), has now been detected in human brain tissue. The activity of 3-hydroxyanthranilate oxygenase is increased in Huntington disease brains as compared to control brains. The increment is particularly pronounced in the striatum, which is known to exhibit the most prominent nerve-cell loss in Huntington disease. Thus, the Huntington disease brain has a disproportionately high capability to produce the endogenous "excitotoxin" quinolinic acid. This finding may be of relevance for clinical, neuropathologic, and biochemical features associated with Huntington disease.
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Cited by
The Role of Excitotoxicity in Neurodegenerative Disease
Doble, A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00042-4 · Cited by 723
Bogan, K. L., & Brenner, C. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155443 · Cited by 707
Kynurenines in the CNS: recent advances and new questions
Vécsei, L., Szalárdy, L., Fülöp, F., & Toldi, J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3793 · Cited by 641
The Ins and Outs of Ring-Cleaving Dioxygenases
Vaillancourt, F. H., Bolin, J. T., & Eltis, L. D. (2006) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230600817422 · Cited by 441
Kynurenines in CNS disease: regulation by inflammatory cytokines.
Campbell, B. M., Charych, E., Lee, A. W., & Möller, T. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00012 · Cited by 409
Metadata
- Authors
- Schwarcz, R., Okuno, E., White, R. J., Bird, E. D., & Whetsell, W. O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-06
- Volume
- 85
- Issue
- 11
- Pages
- 4079-4081
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1983985990
- Cited by
- 184
- References
- 0
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: 3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims. https://app.cochat.ai/papers/10.1073/pnas.85.11.4079
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- Schwarcz, R., Okuno, E., White, R. J., Bird, E. D., & Whetsell, W. O. (1988). 3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.11.4079
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
