The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cell shape controls terminal differentiation of human epidermal keratinocytes.
Open accessAbstract
Cultures of human epidermal keratinocytes provide a useful experimental model with which to study the factors that regulate cell proliferation and terminal differentiation. One situation that is known to trigger premature terminal differentiation is suspension culture, when keratinocytes are deprived of substratum and intercellular contact. We have now investigated whether area of substratum contact, and hence cell shape, can regulate terminal differentiation. Keratinocytes were grown on circular adhesive islands that prevented cell-cell contact. By varying island area we could vary cell shape from fully spread to almost spherical. We found that when substratum contact was restricted, DNA synthesis was inhibited and expression of involucrin, a marker of terminal differentiation, was stimulated. Inhibition of proliferation was not a sufficient stimulus for involucrin synthesis in fully spread cells. When DNA synthesis and involucrin expression were plotted against contact area, classic dose-response curves were obtained. Thus cell shape acts as a signal for the terminal differentiation of keratinocytes in culture.
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Cites
Role of cell shape in growth control
Folkman, J., & Moscona, A. (1978) · Nature · doi:10.1038/273345a0 · Cited by 2,422
How does the extracellular matrix direct gene expression?
Bissell, M. J., Hall, H. G., & Parry, G. (1982) · Journal of Theoretical Biology · doi:10.1016/0022-5193(82)90388-5 · Cited by 1,522
Cited by
Tan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601
Mechanobiology of YAP and TAZ in physiology and disease
Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461
Regulation of development and differentiation by the extracellular matrix
Adams, J. C., & Watt, F. M. (1993) · Development · doi:10.1242/dev.117.4.1183 · Cited by 1,208
Self-citationTransduction of mechanical and cytoskeletal cues by YAP and TAZ
Halder, G., Dupont, S., & Piccolo, S. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3416 · Cited by 985
Role of the extracellular matrix in regulating stem cell fate
Watt, F. M., & Huck, W. T. S. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3620 · Cited by 861
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Metadata
- Authors
- Watt, F. M., Jordan, P. W., & O'Neill, C. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-08
- Volume
- 85
- Issue
- 15
- Pages
- 5576-5580
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2042464350
- Cited by
- 400
- References
- 2
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Watt, F. M., Jordan, P. W., & O'Neill, C. H. (1988). Cell shape controls terminal differentiation of human epidermal keratinocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.15.5576
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
