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Cited by 529

The DOI matches its Crossref record.

A large family of bacterial activator proteins.

Open access
Henikoff, S, Haughn, G W, Calvo, J M, Wallace, J C·1988·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.85.18.6602
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Abstract

At least nine different bacterial proteins belong to the LysR family. The gene sequence for one of these proteins is presented here. Six others (Escherichia coli LysR, IlvY, CysB; Salmonella typhimurium MetR; Rhizobium NodD; and Enterobacter cloacae AmpR) are known to activate other genes. Based on sequence alignments, each member of this family is predicted to have a helix-turn-helix DNA binding motif near its amino terminus. The combined evidence indicates that all nine proteins are related by common ancestry, are similarly folded, and are not detectably related to other known bacterial regulatory proteins. The DNA database searching procedure and other methods used in this study should be useful in detecting other groups of related proteins.

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Metadata

Authors
Henikoff, S., Haughn, G. W., Calvo, J. M., & Wallace, J. C.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1988-09
Volume
85
Issue
18
Pages
6602-6606
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.85.18.6602
OpenAlex
W2156758701
Cited by
529
References
0
FWCI
20.20
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: A large family of bacterial activator proteins. https://app.cochat.ai/papers/10.1073/pnas.85.18.6602
The paper
Henikoff, S., Haughn, G. W., Calvo, J. M., & Wallace, J. C. (1988). A large family of bacterial activator proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.18.6602

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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