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Energetic coupling between DNA bending and base pair opening.
Open accessAbstract
The pathway for base pair opening within a B-DNA duplex is investigated by theoretical molecular modeling. The results show that the disruption of a single base pair is energetically compatible with the deductions made from hydrogen exchange measurements. In addition, it is found that the opening process is greatly facilitated by DNA bending and that, conversely, once a base pair is disrupted, DNA can bend very easily. It appears that the energetic coupling between these two processes may play an important role in many biological reactions involving nucleic acid distortion.
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Metadata
- Authors
- Ramstein, J., & Lavery, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-10
- Volume
- 85
- Issue
- 19
- Pages
- 7231-7235
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978853657
- Cited by
- 298
- References
- 0
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Ramstein, J., & Lavery, R. (1988). Energetic coupling between DNA bending and base pair opening. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.19.7231
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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