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A lamin B receptor in the nuclear envelope.
Open accessAbstract
Using a solution binding assay, we show that purified 125I-labeled lamin B binds in a saturable and specific fashion to lamin-depleted avian erythrocyte nuclear membranes with a Kd of approximately 0.2 microM. This binding is significantly greater than the binding of 125I-labeled lamin A and is competitively inhibited by unlabeled ligand. We demonstrate that a 58-kDa integral membrane protein (p58) is a lamin B receptor by virtue of its abundance in the nuclear envelope and association with 125I-labeled lamin B in ligand blotting assays. Specific antibodies raised against p58 recognize one protein in isolated nuclei and partially block 125I-labeled lamin B binding to lamin-depleted nuclear membranes. Cell fractionation and indirect immunofluorescence microscopy show that p58 is located in the periphery of the nucleus. This protein may serve as a membrane attachment site for the nuclear lamina by acting as a specific receptor for lamin B.
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Cites
Measurement of protein using bicinchoninic acid
Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., & Klenk, D. C. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90442-7 · Cited by 18,482
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Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Wang, N., Tytell, J. D., & Ingber, D. E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2594 · Cited by 1,762
Macromolecular Domains within the Cell Nucleus
Spector, D. L. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.001405 · Cited by 601
Malformation syndromes caused by disorders of cholesterol synthesis
Porter, F. D., & Herman, G. E. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r009548 · Cited by 473
Ye, Q., & Worman, H. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.14653 · Cited by 406
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Metadata
- Authors
- Worman, H. J., Yuan, J., Blobel, G., & Georgatos, S. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-11
- Volume
- 85
- Issue
- 22
- Pages
- 8531-8534
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2010924785
- Cited by
- 370
- References
- 1
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Worman, H. J., Yuan, J., Blobel, G., & Georgatos, S. D. (1988). A lamin B receptor in the nuclear envelope. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.22.8531
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
