The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.
Open accessAbstract
Endothelin releases prostacyclin and thromboxane A2 from guinea pig or rat isolated lungs and endothelium-derived relaxing factor in the perfused mesentery of the rat. Endothelin is also substantially removed by the pulmonary circulation of the rat in vitro and in vivo and by guinea pig lungs in vitro. In the rat, the effects of endothelin on the blood pressure vary from pressor (in pithed rats) to purely depressor in anesthetized rats where the resting blood pressure is high. It therefore has the characteristics of a local pressor hormone, rather than a circulating one.
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Citations
Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Gryglewski, R. J., Moncada, S., & Palmer, R. M. J. (1986) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1986.tb14586.x · Cited by 200
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Endothelial dysfunction and vascular disease - a 30th anniversary update
Vanhoutte, P. M., Shimokawa, H., Feletou, M., & Tang, E. H. C. (2017) · Acta Physiologica · doi:10.1111/apha.12646 · Cited by 937
Brutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697
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Cahill, P. A., & Redmond, E. M. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.03.007 · Cited by 518
Insulin Stimulates Both Endothelin and Nitric Oxide Activity in the Human Forearm
Cardillo, C., Nambi, S. S., Kilcoyne, C. M., Choucair, W. K., Katz, A., Quon, M. J., & Panza, J. A. (1999) · Circulation · doi:10.1161/01.cir.100.8.820 · Cited by 301
Increased plasma endothelin-1 in the early hours of acute myocardial infarction
Stewart, D. J., Kubac, G., Costello, K. B., & Cernacek, P. (1991) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(10)80214-1 · Cited by 295
Metadata
- Authors
- de Nucci, G., Thomas, R., D'Orleans-Juste, P., Antunes, E., Walder, C., Warner, T. D., & Vane, J. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-12
- Volume
- 85
- Issue
- 24
- Pages
- 9797-9800
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2104840130
- Cited by
- 1,400
- References
- 2
- FWCI
- 58.18
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. https://app.cochat.ai/papers/10.1073/pnas.85.24.9797
- The paper
- de Nucci, G., Thomas, R., D'Orleans-Juste, P., Antunes, E., Walder, C., Warner, T. D., & Vane, J. R. (1988). Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.24.9797
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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