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Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter.
Open accessAbstract
A sequence centered 166 nucleotides upstream of the mouse H-2Kb class I major histocompatibility gene binds a nuclear factor, H2TF1, found in many cell types. Previous studies have shown that binding of H2TF1 to this sequence stimulates class I gene expression. Furthermore, this factor binds a similar sequence in the 72-base-pair repeat enhancer element of simian virus 40. We show here that NF-kappa B, an inducible B-cell-specific factor that binds the kappa immunoglobulin light chain gene enhancer, also binds the H2TF1 regulatory sequence. Methylation-interference experiments demonstrate that NF-kappa B closely interacts with six of the eight symmetrically positioned guanines that contact H2TF1. These experiments suggest that NF-kappa B may play a role in class I major histocompatibility gene expression and that H2TF1 and NF-kappa B may be related DNA-binding proteins.
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Citations
Cited by
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
Grilli, M., Chiu, J. J.-S., & Lenardo, M. J. (1993) · International Review of Cytology · doi:10.1016/s0074-7696(08)61873-2 · Cited by 936
Kieran, M., Blank, V., Logeat, F., Vandekerckhove, J., Lottspeich, F., Le Bail, O., Urban, M. B., Kourilsky, P., Baeuerle, P. A., & Israël, A. (1990) · Cell · doi:10.1016/0092-8674(90)90275-j · Cited by 874
Haskill, S., Beg, A. A., Tompkins, S. M., Morris, J. S., Yurochko, A. D., Sampson-Johannes, A., Mondal, K., Ralph, P., & Baldwin, A. S. (1991) · Cell · doi:10.1016/0092-8674(91)90022-q · Cited by 732
Self-citationHTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor
Leung, K., & Nabel, G. J. (1988) · Nature · doi:10.1038/333776a0 · Cited by 586
Zabel, U., Schreck, R., & Baeuerle, P. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52428-5 · Cited by 344
Metadata
- Authors
- Baldwin, A. S., & Sharp, P. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-02
- Volume
- 85
- Issue
- 3
- Pages
- 723-727
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2044634793
- Cited by
- 292
- References
- 0
- FWCI
- 19.69
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter. https://app.cochat.ai/papers/10.1073/pnas.85.3.723
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- Baldwin, A. S., & Sharp, P. A. (1988). Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.3.723
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
