The DOI matches its Crossref record.
Characterization and expression of a cDNA encoding the human androgen receptor.
Open accessAbstract
We report the isolation of a cDNA that encodes the complete human androgen receptor. The cDNA predicts a protein of 917 amino acids with a molecular weight of 98,918. Introduction of the cDNA into heterologous mammalian cells caused expression of high levels of a protein that binds dihydrotestosterone with the affinity, specificity, and sedimentation properties characteristic of the native human androgen receptor. Comparisons with the amino acid sequence of previously cloned steroid hormone receptors revealed a high degree of sequence conservation with the progesterone, glucocorticoid, and mineralocorticoid receptors in the putative hormone and DNA-binding domain regions.
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Cited by
Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481
Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Pieretti, M., Sutcliffe, J. S., Richards, S., Verkert, A. J. M. H., Holden, J. J. A., Fenwick, R. G., Warren, S. T., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90283-5 · Cited by 2,080
Androgen Receptor Defects: Historical, Clinical, and Molecular Perspectives*
QUIGLEY, C. A., BELLIS, A. D., MARSCHKE, K. B., EL-AWADY, M. K., WILSON, E. M., & FRENCH, F. S. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-271 · Cited by 1,447
Compilation of vertebrate-encoded transcription factors
Faisst, S., & Meyer, S. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.1.3 · Cited by 914
Androgen Receptor (AR) Coregulators: An Overview
Heinlein, C. A., & Chang, C. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0460 · Cited by 943
Metadata
- Authors
- Tilley, W. D., Marcelli, M., Wilson, J. D., & McPhaul, M. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-01
- Volume
- 86
- Issue
- 1
- Pages
- 327-331
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1967932707
- Cited by
- 476
- References
- 0
- FWCI
- 16.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Tilley, W. D., Marcelli, M., Wilson, J. D., & McPhaul, M. J. (1989). Characterization and expression of a cDNA encoding the human androgen receptor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.1.327
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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