The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Characterization of human cardiac myosin heavy chain genes.
Open accessAbstract
We have isolated and analyzed the structure of the genes coding for the alpha and beta forms of the human cardiac myosin heavy chain (MYHC). Detailed analysis of four overlapping MYHC genomic clones shows that the alpha-MYHC and beta-MYHC genes constitute a total length of 51 kilobases and are tandemly linked. The beta-MYHC-encoding gene, predominantly expressed in the normal human ventricle and also in slow-twitch skeletal muscle, is located 4.5 kilobases upstream of the alpha-MYHC-encoding gene, which is predominantly expressed in normal human atrium. We have determined the nucleotide sequences of the beta form of the MYHC gene, which is 100% homologous to the cardiac MYHC cDNA clone (pHMC3). It is unlikely that the divergence of a few nucleotide sequences from the cardiac beta-MYHC cDNA clone (pHMC3) reported in a MYHC cDNA clone (pSMHCZ) from skeletal muscle is due to a splicing mechanism. This finding suggests that the same beta form of the cardiac MYHC gene is expressed in both ventricular and slow-twitch skeletal muscle. The promoter regions of both alpha- and beta-MYHC genes, as well as the first four coding regions in the respective genes, have also been sequenced. The sequences in the 5'-flanking region of the alpha- and beta-MYHC-encoding genes diverge extensively from one another, suggesting that expression of the alpha- and beta-MYHC genes is independently regulated.
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“Supporting this, a high similarity in amino acid sequences between 2 human MyHC isoforms (93%) has been identified. 47,280,281”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [280]
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Cites
The isolation of structural genes from libraries of eucaryotic DNA
Maniatis, T., Hardison, R. C., Lacy, E., Lauer, J., O'Connell, C., Quon, D. H., Sim, G.-K., & Efstratiadis, A. (1978) · Cell · doi:10.1016/0092-8674(78)90036-3 · Cited by 1,826
Hoh, J. (1978) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(78)90401-7 · Cited by 770
Lompré, A., Nadal-Ginard, B., & Mahdavi, V. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82162-0 · Cited by 615
Myosin isoenzyme redistribution in chronic heart overload
Lompré, A., Schwartz, K., d’Albis, A., Lacombe, G., Thiem, N. V., & Bernard Swynghedauw, A. (1979) · Nature · doi:10.1038/282105a0 · Cited by 523
Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.
Mahdavi, V., Chambers, A. P., & Nadal-Ginard, B. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.9.2626 · Cited by 328
[58] DNA sequence analysis by primed synthesis
Smith, A. J. H. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65060-5 · Cited by 280
Molecular characterization of two myosin heavy chain genes expressed in the adult heart
Mahdavi, V., Periasamy, M., & Nadal‐Ginard, B. (1982) · Nature · doi:10.1038/297659a0 · Cited by 278
Complete nucleotide and encoded amino acid sequence of a mammalian myosin heavy chain gene
Strehler, E. E., Strehler-Page, M. A., Perriard, J., Periasamy, M., & Nadal‐Ginard, B. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90003-3 · Cited by 264
Developmental and hormonal regulation of sarcomeric myosin heavy chain gene family.
Mahdavi, V., Izumo, S., & Nadal-Ginard, B. (1987) · Circulation Research · doi:10.1161/01.res.60.6.804 · Cited by 202
Human cardiac myosin heavy chain genes and their linkage in the genome
Sáez, L., Gianola, K. M., McNally, E. M., Feghali, R., Eddy, R. L., Shows, T. B., & Leinwand, L. A. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.13.5443 · Cited by 165
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Ohno-miRNAs: miRNA pairs derived from whole-genome duplication
Agasso, L., Molineris, I., & Caselle, M. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013766
Immature and mature myocardium in the pathophysiology of hypertrophic cardiomyopathy
Federspiel, J. M., Medarev, S. L., Pfeifer, J., Jani, V., Pinto, J. R., & Landim-Vieira, M. (2026) · Journal of Molecular and Cellular Cardiology Plus · doi:10.1016/j.jmccpl.2026.100859
Regulators of Muscle Gene Expression
Barton, P. J. R., Boheler, K. R., Brand, N. J., & Thomas, P. S. (1995) · Medical intelligence unit · doi:10.1007/978-3-662-22192-1_4
Metadata
- Authors
- Yamauchi-Takihara, K., Sole, M. J., Liew, J., Ing, D., & Liew, C. C.
- Affiliations
- Department of Medicine, Max Bell Research Center, Toronto General Hospital, University of Toronto, ON, Canada.
- University of Toronto (CA)
- ORCID
- Liew, J
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1989-05
- Volume
- 86
- Issue
- 10
- Pages
- 3504-3508
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC298074
- OpenAlex
- W2066873880
- Cited by
- 103
- References
- 25
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- cardiac myosin heavy chain, gene structure, promoter, 5'-flanking region, slow-twitch muscle, ventricular myocardium, atrial muscle, gene expression regulation, alternative splicing
- MeSH terms
- Amino Acid Sequence, Base Sequence, Cloning, Molecular, Genes, Humans, Molecular Sequence Data, Myocardium, Myosins, Blotting, Southern, Restriction Mapping
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