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Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family.
Open accessAbstract
Recently, hematopoietic stem cells were purified to homogeneity from mouse bone marrow. The protein structure of Sca-1, the cell surface antigen used in the isolation of hematopoietic stem cells, is described here. It is shown that the Sca-1 antigen is a member of the Ly-6 antigen family. The anti-Sca-1 antibody was used in immunohistochemistry experiments to define the structures in several tissues that had previously been shown to contain Ly-6 antigens. In thymus, spleen, and kidney, specific staining of parenchymal cells can be demonstrated, whereas only vasculature reacts with anti-Sca-1 in brain, heart, and liver and possibly in lung.
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Citations
Cited by
A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
Matthews, W., Jordan, C. T., Wiegand, G. W., Pardoll, D., & Lemischka, I. R. (1991) · Cell · doi:10.1016/0092-8674(91)90010-v · Cited by 593
ABC Transporters as Phenotypic Markers and Functional Regulators of Stem Cells
Bunting, K. D. (2002) · STEM CELLS · doi:10.1002/stem.200011 · Cited by 458
Morgan, B., Sun, L., Avitahl, N., Andrikopoulos, K., Ikeda, T., Gonzales, E., Wu, P., Neben, S., & Georgopoulos, K. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.2004 · Cited by 367
Bipotential precursors of B cells and macrophages in murine fetal liver
Cumano, A., Paige, C. J., Iscove, N. N., & Brady, G. (1992) · Nature · doi:10.1038/356612a0 · Cited by 349
Huang, Q., Chan, K. Y., Tobey, I. G., Chan, Y. A., Poterba, T., Boutros, C. L., Balazs, A. B., Daneman, R., Bloom, J. M., Seed, C., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0225206 · Cited by 234
Metadata
- Authors
- van de Rijn, M., Heimfeld, S., Spangrude, G. J., & Weissman, I. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-06
- Volume
- 86
- Issue
- 12
- Pages
- 4634-4638
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2104931922
- Cited by
- 265
- References
- 0
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family. https://app.cochat.ai/papers/10.1073/pnas.86.12.4634
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- van de Rijn, M., Heimfeld, S., Spangrude, G. J., & Weissman, I. L. (1989). Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.12.4634
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