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Cited by 265

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Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family.

Open access
van de Rijn, M, Heimfeld, S, Spangrude, G J, Weissman, I L·1989·Proceedings of the National Academy of Sciences

Abstract

Recently, hematopoietic stem cells were purified to homogeneity from mouse bone marrow. The protein structure of Sca-1, the cell surface antigen used in the isolation of hematopoietic stem cells, is described here. It is shown that the Sca-1 antigen is a member of the Ly-6 antigen family. The anti-Sca-1 antibody was used in immunohistochemistry experiments to define the structures in several tissues that had previously been shown to contain Ly-6 antigens. In thymus, spleen, and kidney, specific staining of parenchymal cells can be demonstrated, whereas only vasculature reacts with anti-Sca-1 in brain, heart, and liver and possibly in lung.

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Metadata

Authors
van de Rijn, M., Heimfeld, S., Spangrude, G. J., & Weissman, I. L.
Venue
Proceedings of the National Academy of Sciences
Published
1989-06
Volume
86
Issue
12
Pages
4634-4638
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2104931922
Cited by
265
References
0
FWCI
3.73
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family. https://app.cochat.ai/papers/10.1073/pnas.86.12.4634
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van de Rijn, M., Heimfeld, S., Spangrude, G. J., & Weissman, I. L. (1989). Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.12.4634

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.