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Two steps in the evolution of Antennapedia-class vertebrate homeobox genes.
Open accessAbstract
Antennapedia-class vertebrate homeobox genes have been classified with regard to their chromosomal locations and nucleotide sequence similarities within the 183-base-pair homeobox domain. The results of these comparisons support the view that in mammals and most likely the vertebrates, four clusters of homeobox genes exist that were created by duplications of an entire primordial gene cluster. We present evidence that this primordial cluster arose by local gene duplications of homeoboxes that were present before the divergence of arthropods and chordates. Sequence analyses indicate that the expansion of the primordial gene cluster complex was accompanied by diversification, whereas conservation predominated after the duplications of entire homeobox gene clusters.
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Cited by
The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster
Brooke, N. M., Garcia-Fernàndez, J., & Holland, P. W. H. (1998) · Nature · doi:10.1038/31933 · Cited by 468
PARALOGOUS HOX GENES: Function and Regulation
Maconochie, M., Nonchev, S., Morrison, A., & Krumlauf, R. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.529 · Cited by 220
Chapter 8 Hox Genes and Segmentation of the Vertebrate Hindbrain
Tümpel, S., Wiedemann, L. M., & Krumlauf, R. (2009) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)88004-6 · Cited by 150
Metadata
- Authors
- Kappen, C., Schughart, K., & Ruddle, F. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-07
- Volume
- 86
- Issue
- 14
- Pages
- 5459-5463
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2033583033
- Cited by
- 210
- References
- 0
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Kappen, C., Schughart, K., & Ruddle, F. H. (1989). Two steps in the evolution of Antennapedia-class vertebrate homeobox genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.14.5459
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