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Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene.
Open accessAbstract
The c-myb protooncogene encodes a sequence-specific DNA-binding protein (c-Myb) that induces transcriptional activation or repression. We have identified three functional domains of the mouse c-Myb protein that are responsible for DNA binding, transcriptional activation, and negative regulation, respectively. In addition to the DNA-binding domain, which is located near the N terminus, an adjacent region (the transcriptional activation domain) containing about 80 amino acids was found to be essential for transcriptional activation. Deletion of a region spanning about 175 amino acids of the C-proximal portion increased transcriptional activation markedly, revealing that this domain normally represses activation. Differences between the transcriptional activation and repression functions of c-Myb and v-Myb are discussed in the light of these functional domains. Our results suggest that transcriptional activation may be involved in transformation by myb gene products.
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Cited by
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
Mucenski, M. L., McLain, K., Kier, A. B., Swerdlow, S. H., Schreiner, C. M., Miller, T. A., Pietryga, D. W., Scott, W. J., & Potter, S. S. (1991) · Cell · doi:10.1016/0092-8674(91)90099-k · Cited by 1,042
Persson, M., Andrén, Y., Mark, J., Horlings, H. M., Persson, F., & Stenman, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909114106 · Cited by 788
Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α
Jiang, B.-H., Zheng, J. Z., Leung, S. W., Roe, R., & Semenza, G. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19253 · Cited by 629
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Oh, I.-H., & Reddy, E. P. (1999) · Oncogene · doi:10.1038/sj.onc.1202839 · Cited by 498
Ogata, K., Morikawa, S., Nakamura, H., Sekikawa, A., Inoue, T., Kanai, H., Sarai, A., Ishii, S., & Nishimura, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90549-5 · Cited by 489
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Metadata
- Authors
- Sakura, H., Kanei-Ishii, C., Nagase, T., Nakagoshi, H., Gonda, T. J., & Ishii, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-08
- Volume
- 86
- Issue
- 15
- Pages
- 5758-5762
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2089779712
- Cited by
- 333
- References
- 0
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Sakura, H., Kanei-Ishii, C., Nagase, T., Nakagoshi, H., Gonda, T. J., & Ishii, S. (1989). Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.15.5758
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