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A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting.
Open accessAbstract
Embryonal rhabdomyosarcomas (malignant pediatric tumors of striated muscle origin) have been shown to arise from cells that are clonally isodisomic for loci on chromosome 11p. We determined the parental origin of alleles in this genomic region in familial and sporadic cases of this disease and found that isodisomic chromosome 11p alleles in each tumor were of paternal origin. We have developed a modification of Knudson's two-hit model from these data that is capable of explaining the preferential allele retention and of resolving the apparent contradiction between such specific and early events in several embryonal tumors and discrepancies in the inheritance of predisposition in some of these diseases.
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Cited by
The history of cancer epigenetics
Feinberg, A. P., & Tycko, B. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1279 · Cited by 2,344
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Feinberg, A. P. (2007) · Nature · doi:10.1038/nature05919 · Cited by 1,613
Tumour-suppressor activity of H19 RNA
Hao, Y., Crenshaw, T., Moulton, T., Newcomb, E., & Tycko, B. (1993) · Nature · doi:10.1038/365764a0 · Cited by 630
Genomic Imprinting: Implications for Human Disease
Falls, J. G., Pulford, D. J., Wylie, A. A., & Jirtle, R. L. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65309-6 · Cited by 359
Lee, M. P., Hu, R.-J., Johnson, L. A., & Feinberg, A. P. (1997) · Nature Genetics · doi:10.1038/ng0297-181 · Cited by 356
Metadata
- Authors
- Scrable, H., Cavenee, W., Ghavimi, F., Lovell, M., Morgan, K., & Sapienza, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-10
- Volume
- 86
- Issue
- 19
- Pages
- 7480-7484
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093352272
- Cited by
- 261
- References
- 0
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting. https://app.cochat.ai/papers/10.1073/pnas.86.19.7480
- The paper
- Scrable, H., Cavenee, W., Ghavimi, F., Lovell, M., Morgan, K., & Sapienza, C. (1989). A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.19.7480
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
