The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Organization of the human lipoprotein lipase gene and evolution of the lipase gene family.
Open accessAbstract
The human lipoprotein lipase gene was cloned and characterized. It is composed of 10 exons spanning approximately equal to 30 kilobases. The first exon encodes the 5'-untranslated region, the signal peptide plus the first two amino acids of the mature protein. The next eight exons encode the remaining 446 amino acids, and the tenth exon encodes the long 3'-untranslated region of 1948 nucleotides. The lipoprotein lipase transcription start site and the sequence of the 5'-flanking region were also determined. We compared the organization of genes for lipoprotein lipase, hepatic lipase, pancreatic lipase, and Drosophila yolk protein 1, which are members of a family of related genes. A model for the evolution of the lipase gene family is presented that involves multiple rounds of gene duplication plus exon-shuffling and intron-loss events.
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Cites
Needleman, S. B., & Wunsch, C. D. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90057-4 · Cited by 11,288
Cited by
Lipoprotein lipase: from gene to obesity
Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 741
van Tilbeurgh, H., Egloff, M.-P., Martinez, C., Rugani, N., Verger, R., & Cambillau, C. (1993) · Nature · doi:10.1038/362814a0 · Cited by 686
Merkel, M., Eckel, R. H., & Goldberg, I. J. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200015-jlr200 · Cited by 522
DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene
Nickerson, D. A., Taylor, S. L., Weiss, K. M., Clark, A. G., Hutchinson, R. G., Stengård, J., Salomaa, V., Vartiainen, E., Boerwinkle, E., & Sing, C. F. (1998) · Nature Genetics · doi:10.1038/907 · Cited by 476
Wong, H., & Schotz, M. C. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200007-jlr200 · Cited by 298
Metadata
- Authors
- Kirchgessner, T. G., Chuat, J. C., Heinzmann, C., Etienne, J., Guilhot, S., Svenson, K., Ameis, D., Pilon, C., d'Auriol, L., & Andalibi, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-12
- Volume
- 86
- Issue
- 24
- Pages
- 9647-9651
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1980756034
- Cited by
- 229
- References
- 1
- FWCI
- 20.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Kirchgessner, T. G., Chuat, J. C., Heinzmann, C., Etienne, J., Guilhot, S., Svenson, K., Ameis, D., Pilon, C., d'Auriol, L., & Andalibi, A. (1989). Organization of the human lipoprotein lipase gene and evolution of the lipase gene family. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.24.9647
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