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Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence.
Open accessAbstract
Filamentous hemagglutinin is a surface-associated adherence protein of Bordetella pertussis, which is a component of some new acellular pertussis vaccines. The nucleotide sequence of an open reading frame that encompasses the filamentous hemagglutinin structural gene, fhaB, suggests that proteolytic processing is necessary to generate the mature 220-kDa filamentous hemagglutinin product. An Arg-Gly-Asp (RGD) tripeptide is found within filamentous hemagglutinin that may be involved in its adherence properties. An internal in-frame deletion in fhaB, encompassing the RGD region, causes loss of B. pertussis-binding to ciliated eukaryotic cells, confirming a potential role for this protein in host-cell binding and infection.
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Cited by
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Hultgren, S. J., Abraham, S., Caparon, M., Falk, P., Geme, J. W. S., & Normark, S. (1993) · Cell · doi:10.1016/0092-8674(93)90269-v · Cited by 409
Leininger, E., Roberts, M., Kenimer, J. G., Charles, I. G., Fairweather, N., Novotny, P., & Brennan, M. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.2.345 · Cited by 296
Surface-associated filamentous hemagglutinin induces autoagglutination of Bordetella pertussis
Menozzi, F. D., Boucher, P. E., Riveau, G., Gantiez, C., & Locht, C. (1994) · Infection and Immunity · doi:10.1128/iai.62.10.4261-4269.1994 · Cited by 104
Phase-variable outer membrane proteins in Escherichia coli
Owen, P., Meehan, M., de Loughry-Doherty, H., & Henderson, I. (1996) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1996.tb00124.x · Cited by 88
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Costello, M. S., Neumann, B., Raimondi, M. W., Cuthbert, B. J., Holubová, J., Garza-Sánchez, F., Samad, A., Bumba, L., Torres, J. A., Holznecht, N., et al. (2026) · Science · doi:10.1126/science.adz2737 · Cited by 7
Metadata
- Authors
- Relman, D. A., Domenighini, M., Tuomanen, E., Rappuoli, R., & Falkow, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-04
- Volume
- 86
- Issue
- 8
- Pages
- 2637-2641
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2001249476
- Cited by
- 350
- References
- 0
- FWCI
- 20.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Relman, D. A., Domenighini, M., Tuomanen, E., Rappuoli, R., & Falkow, S. (1989). Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.8.2637
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