The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.
Open accessAbstract
We have recently shown that viable Borrelia burgdorferi organisms induce a chronic infection associated with arthritis and carditis in severe combined immunodeficiency (scid) mice but not in immunocompetent mice. The disease is similar to that found in patients suffering from Lyme disease. We now show that B. burgdorferi-specific immune mouse sera as well as a monoclonal antibody to the spirochetal outer surface antigen A (31 kDa) but not monoclonal antibodies specific for the 41-kDa antigenic component of the periplasmic flagella are able to prevent (or mitigate) the development of the disease in scid mice when passively transferred at the time of the bacterial inoculation. The identification of a B. burgdorferi-associated protective antigen suggests that the corresponding spirochetal protein should be tested as a vaccine against Lyme disease.
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Cites
The Spirochetal Etiology of Lyme Disease
Steere, A. C., Grodzicki, R. L., Kornblatt, A. N., Craft, J. E., Barbour, A. G., Burgdorfer, W., Schmid, G. P., Johnson, E., & Malawista, S. E. (1983) · New England Journal of Medicine · doi:10.1056/nejm198303313081301 · Cited by 1,573
A Borrelia-specific monoclonal antibody binds to a flagellar epitope
Barbour, A. G., Hayes, S. F., Heiland, R. A., Schrumpf, M. E., & Tessier, S. L. (1986) · Infection and Immunity · doi:10.1128/iai.52.2.549-554.1986 · Cited by 358
Bergström, S., Bundoc, V. G., & Barbour, A. G. (1989) · Molecular Microbiology · doi:10.1111/j.1365-2958.1989.tb00194.x · Cited by 310
Antigenic Variability of Borrelia burgdorferi
Wilske, B., Preac‐Mursic, V., Schierz, G., et al. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb31846.x · Cited by 278
Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete.
Barbour, A. G., Burgdorfer, W., Grunwaldt, E., & Steere, A. C. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110998 · Cited by 189
Experimental Lyme Arthritis in Rats Infected with Borrelia burgdorferi
Barthold, S. W., Moody, K. D., Terwilliger, G. A., Duray, P. H., Jacoby, R. O., & Steere, A. C. (1988) · The Journal of Infectious Diseases · doi:10.1093/infdis/157.4.842 · Cited by 139
Passive immunization of hamsters against experimental infection with the Lyme disease spirochete
Johnson, R. C., Kodner, C. B., & Russell, M. (1986) · Infection and Immunity · doi:10.1128/iai.53.3.713-714.1986 · Cited by 123
MUNDER, P. G., Modolell, M., & Wallach, D. F. H. (1971) · FEBS Letters · doi:10.1016/0014-5793(71)80309-5 · Cited by 82
Self-citationBiological Activity of Borrelia burgdorferi Antigensa
Benach, J. L., Coleman, J. L., García‐Moncó, J. C., et al. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb31845.x · Cited by 63
Cited by
Steere, A. C., Sikand, V. K., Meurice, F., Parenti, D. L., Fikrig, E., Schoen, R. T., Nowakowski, J., Schmid, C. H., Laukamp, S., Buscarino, C., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807233390401 · Cited by 746
Protection against tick-transmitted Lyme disease in dogs vaccinated with a multiantigenic vaccine
Straubinger, R. K., Dharma Rao, T., Davidson, E., Summers, B. A., Jacobson, R. H., & Frey, A. B. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00251-1 · Cited by 23
Safety, efficacy and immunogenicity of a recombinant Osp subunit canine Lyme disease vaccine
Ma, J., Hine, P. M., Clough, E. R., Fish, D., Coughlin, R. T., Beltz, G. A., & Shew, M. G. (1996) · Vaccine · doi:10.1016/s0264-410x(96)00045-x · Cited by 21
Metadata
- Authors
- Schaible, U. E., Kramer, M. D., Eichmann, K., Modolell, M., Museteanu, C., & Simon, M. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-05
- Volume
- 87
- Issue
- 10
- Pages
- 3768-3772
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1979072305
- Cited by
- 273
- References
- 9
- FWCI
- 24.16
- Type
- journal article
- Language
- en
- Open access
- green
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- This page
- CoChat. (2026). Citation check: Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. https://app.cochat.ai/papers/10.1073/pnas.87.10.3768
- The paper
- Schaible, U. E., Kramer, M. D., Eichmann, K., Modolell, M., Museteanu, C., & Simon, M. M. (1990). Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.10.3768
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
