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Lipid biophysics of water loss through the skin.
Open accessAbstract
The regulation of water loss through the skin is a poorly understood but crucial process in maintaining terrestrial life-forms. In mammalian skin, the outermost layer, called the stratum corneum (SC), is rate-limiting to water loss. We have evaluated temperature-dependent changes in water vapor permeability and infrared spectra of porcine SC. In particular, we have analyzed the infrared absorption peaks due to the extracellular lipids of the SC. These results show a remarkable correlation between water permeability and the frequency of the C-H stretching vibrations over a broad range of temperature. Since the spectral changes reflect an increased number of alkyl gauche conformers, these results suggest that water permeability is dependent upon the hydrocarbon-chain disorder of SC lipids.
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Cited by
Stratum Corneum Defensive Functions: An Integrated View
Elias, P. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23668.x · Cited by 772
Transdermal drug delivery: overcoming the skin’s barrier function
Naik, A., Kalia, Y. N., & Guy, R. H. (2000) · Pharmaceutical Science & Technology Today · doi:10.1016/s1461-5347(00)00295-9 · Cited by 720
Electroporation: A general phenomenon for manipulating cells and tissues
Weaver, J. C. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.2400510407 · Cited by 489
Yu, Y.-Q., Yang, X., Wu, X.-F., & Fan, Y.-B. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.646554 · Cited by 441
Electroporation of cells and tissues
Weaver, J. C. (2000) · IEEE Transactions on Plasma Science · doi:10.1109/27.842820 · Cited by 353
Metadata
- Authors
- Potts, R. O., & Francoeur, M. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-05
- Volume
- 87
- Issue
- 10
- Pages
- 3871-3873
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2068921992
- Cited by
- 244
- References
- 0
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Lipid biophysics of water loss through the skin. https://app.cochat.ai/papers/10.1073/pnas.87.10.3871
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- Potts, R. O., & Francoeur, M. L. (1990). Lipid biophysics of water loss through the skin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.10.3871
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