The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation.
Open accessAbstract
We have shown that the transcriptional activity of the protooncogene jun (c-jun) promoter is repressed by a transcription factor, the cAMP response element-binding protein (CREB). This repression can be alleviated when CREB is phosphorylated by the catalytic subunit of protein kinase A. Repression cannot be alleviated by a mutant CREB deficient in the protein kinase A phosphorylation site (M1 CREB Ser-133----Ala), suggesting that phosphorylation of CREB at this site is essential for the relief of repression. Repression by CREB requires its binding to the c-jun promoter. In NIH 3T3 cells stably expressing CREB, c-jun is no longer induced by serum, but this repression can be relieved by treatment of the cells with forskolin, an agonist of the adenylate cyclase pathway. Thus, CREB has a dual function, that of a repressor in the absence of phosphorylation and an activator when phosphorylated by protein kinase A.
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Citations
Cites
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
Angel, P., Hattori, K., Smeal, T., & Karin, M. (1988) · Cell · doi:10.1016/0092-8674(88)90143-2 · Cited by 1,239
Cited by
Hunter, T. (1991) · Cell · doi:10.1016/0092-8674(91)90637-e · Cited by 767
MEYER, T. E., & HABENER, J. F. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-3-269 · Cited by 468
PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation
Peltier, J., O'Neill, A., & Schaffer, D. V. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20506 · Cited by 443
The plasminogen activator system: biology and regulation
Irigoyen, J. P., Muñoz-Cánoves, P., Montero, L., Koziczak, M., & Nagamine, Y. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000615 · Cited by 368
Fields, R. D., Eshete, F., Stevens, B., & Itoh, K. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07252.1997 · Cited by 316
Metadata
- Authors
- Lamph, W. W., Dwarki, V. J., Ofir, R., Montminy, M., & Verma, I. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-06
- Volume
- 87
- Issue
- 11
- Pages
- 4320-4324
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1980854045
- Cited by
- 219
- References
- 1
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Lamph, W. W., Dwarki, V. J., Ofir, R., Montminy, M., & Verma, I. M. (1990). Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.11.4320
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
